17^th Annual Medicinal & Pharmaceutical Sciences Congress July 05-06, 2018 Bangkok, Thailand

Biography:

Dr. Ramakrishna Shabaraya has completed B.Pharm in 1995, M.Pharm in 1997, Ph.D in 2007 and MBA in 2015. He has published more than 60 research publications in National and international journals & presented in International conferences i.e France, Australia, New Orleans, Malaysia & Dubai. He has successfully guided 25 M.Pharm and 5 Ph.D students. He has received many travel grants, research and seminar grants. He has authored a book entitled “A detailed study on HIV and its drugs” published by Lambert Academic publishing house. He was awarded NATIONAL EDUCATION LEADERSHIP AWARD by Economic Growth society of India New Delhi.

Abstract:

Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. Artesunate having a short half life of 2-3hrs upon oral administration and is a lipophilic in nature is used for the treatment of malaria, was encapsulated in liposomes. The liposomes containing Artesunate were prepared using thin film hydration method. In this study, PEGylated and conventional liposomes containing artesunate were prepared using varying drug-lipid ratio and were characterized for their particle size, zeta potential, encapsulation efficiency, and in-vitro drug release studies. The drug encapsulation efficiency of PEGylated liposomes was found to be higher in comparison to conventional liposomes. The average particle size of both conventional and PEGylated liposomes was obtained in nanometers with PDI ranging from 0.095-0.356. The PEGylated liposomes were found to be more stable than the traditional liposomes through the zeta potential studies. In-vitro drug diffusion studies was carried for period of 16 hrs where PEGylated liposomal formulation  showed around 80.99% sustained drug release which was more than the conventional liposomes. The PEGylated liposomal formulations followed Higuchi model where as conventional liposomal formulations followed zero order kinetics.

Biography:

Chander Pal Verma is currently Professor & Head, Department of Pharmacognosy & Phytochemistry and the Dean Student Welfare in the Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh, India.   Professor Verma has worked under Ministry of Health, Kingdom of Saudi Arabia as Professor of Pharmacy in Bisha College of Pharmacy. Prior to this he graduated from Delhi University with a first class honours degree in Pharmaceutical Sciences (1982) and was then awarded a Post Graduation in Phamacognosy & Phytochemistry from Delhi Universiy (1984).  In 2018, Professor Verma was awarded with Eminent Teachers Award by Society of Pharmaceutical Education and Research at Crescent University Chennai, India.  He has been Chairman and Member of LOC for reputed International / National Conferences like, SPER 7th Annual International Conference & Exhibition 2018, 69th IPC. He has chaired many scientific sessions at conferences of IPC, SPER etc. He has been Mentor Speaker for Himachal Pradesh State Pharmacy Council in Continuing Education Programmes. Under his visionary leadership as a President, Drug Information Centre, Himachal Pradesh, he has served the rural society of Himachal Pradesh. He has worked as Moderator for Himachal Pradesh Technical University. He serves as an examiner for UG and PG courses at various Universities. Prof. Verma is recognized Inspector for various apex bodies like Pharmacy Council of India, New delhi.

Abstract:

Drugs that are administered orally go through a dissolution process and then permeation across the gastric membrane before they can appear in the blood stream. Some factors that affect the amount of drug available for its effect (the bioavailability of the drug) other than solubility and permeability are dissolution rate of the drug, first-pass effect, pre-systemic metabolism of the drug in any other organ, and susceptibility to efflux mechanisms. Solubility of the drug in the gastric media is a major problem with most drugs. This leads to erratic bioavailability and possible toxicity when eventually absorbed through the gastric mucosa. Thus, solubility of new drug molecules is the biggest challenge for formulation scientists.

In spite of these issues, the oral route of drug administration has been the most sought after route due to its ease of administration, high patient compliance, cost-effectiveness, least need for maintenance of sterile conditions, and flexibility in design of the dosage form. The first attempt by pharmaceutical companies in making generic drugs is to formulate the drug as an oral dosage form. The pharmaceutical industry is experimenting with various techniques for improving the solubility of the drug post oral administration. The techniques used for improving the solubility characteristics of a drug can be very broadly classified as either physical or chemical processes.

Solid dispersions, a dispersion of one or more active ingredients in an inert carrier or matrix in the solid state prepared by co-melting or solvent extraction or by the solvent-melt method. Solid dispersion technology is a technique which has comparatively fewer problems. It does have some disadvantages associated with it such as the possibility of recrystallization upon storage or during the various pharmaceutical processes. Moisture might increase the mobility of the drug, thereby increasing the chances of recrystallization. Some other draw backs include not being able to scale up the process satisfactorily and requiring extra processing steps before the product can be put through any other process. Some of the problems associated with the properties of the solid dispersions and the need for more processing can be easily overcome by using an adsorbent and forming a ternary solid dispersion, a Drug Composite.

The concept of ‘bioavailability enhancers’ is derived from the traditional age old system of Ayurveda (science of life) . These enhancers not only improve the solubility of drug but also significantly have effect on our biological systems. These effects are generally beneficial either in providing efficacy or safety of the drug. Aloe Vera gel or Piperine has shown improved bioavailability of various drugs. 

Low aqueous solubility is a major problem faced during formulation development of new drug molecules. A drug having problems associated with low aqueous solubility, poor bioavailability and slow onset of action will be selected as model drug.

Hence, purpose of this Presentation is to provide fast dissolving composites of Model Drug using natural bioavailability enhancers.

Biography:

Dr. surendra Lalwani, received his doctorate degree from Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar. He did his B-Pharmacy and M-Pharmacy in pharmaceutical chemistry from Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar. His area of research focuses on Photodynamic therapy (PDT) and anti-cancer activities. He is associated with various academic and scientific bodies as a life member of Indian Pharmaceutical Association, Indian Pharmacy Graduate Association, and Association of Pharmaceutical Teachers of India, Indian association of cancer research, Indian chemistry teachers association, International society of infectious disease Dr. Lalwani is Subject Expert of the various institutes/colleges/Universities in the country. He joined as a speaker at Pharmacoepidemiology Congress 2017 in Kuala Lumpur, Malaysia. Dr. Lalwani is a Reviewer/Referee of a number of national and international research journals. He had been awarded with Junior Research Fellow by UGC, New Delhi, India. Dr. Lalwani has 18 years of teaching experience. Presently he is working as a principal at Metro College of Health Sciences & Research, Metro College of Pharmacy Greater Noida.

Abstract:

Extended release pharmaceutical products became a very useful tool in medical practice, offering a wide range of actual and perceived advantages to the patient. Oral extended release drug delivery system becomes a promising approach for those drugs that are given orally, having the shorter half- life and high dosing frequency. Extended release provides promising way to decrease the side effect of the drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. Recent trends indicate that multi particulate drug delivery systems are especially suitable for achieving extended release oral formulations with low risk of drug dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. The release of drug from pellets depends on the variety of factors including the carrier used to form pellets and the amount of drug contained in them. Consequently, pellets provide tremendous opportunities for designing new controlled and extended release oral formulations, thus extending the frontier of future pharmaceutical development. In the present study extended release tablets of Metformin hydrochloride (an oral antihyperglycemic drug) were formulated by using polymers of different viscosity grade such as HPMC K4M, HPMC K15M, HPMC K100M by wet granulation method. The formulated granules blends were evaluated for compatibility, angle of repose, true density, bulk density, compressibility index. The formulated tablets were subjected to thickness, weight variation test, hardness test, friability test and drug content. In vitro dissolution studies carried out in 6.8 phosphate buffer using the apparatus Type 2 paddle type as described in the USP dissolution monograph. The best extended performance and the best in vitro drug release profile were achieved by formulation F5 which contains drug; HPMC K4M in a ratio of 1:6. The tablets were released the drug up to 12hr and had maximum extended lag time. There was no significant change in physical and chemical properties of the tablets of formulation F5 after 3 Months, parameters like % drug release and assay values at various conditions as per ICH guidelines.

Biography:

Dr. L. K. Omray did B. Pharmacy, M. Pharmacy and Ph.D from Dr. Harisingh Gour University, Sagar, India. Presently he is a Director at Radharaman Institute of Pharmaceutical Sciences, India. He is having 20 years of industrial and educational experiences.

Abstract:

Viral infection present on skin surface requires both systemic and tropical/ transdermal due to lesser availability of drug at skin surface. Present study deals with the development of acyclovir containing solid lipid nanoparticles for transdermal/ topical drug delivery. Solid lipid nanoparticles of acyclovir were prepared by ether injection method. Solid lipid nanoparticles were prepared by acyclovir, glyceryl mono stearate, brij 35, propylene glycol, liquid paraffin and double distilled water. Total five formulations i.e. F1 to F5 were prepared in different quantity of brij 35. All the solid lipid nanoparticles formulations were characterized on the basis of viscosity, electron microscopy, particle size by zeta sizer, polydispersity index, encapsulation efficiency, and in vitro drug release study. Viscosity of the formulation was found from 3190 to 3850 cp. Average size of solid lipid nanoparticles and polydispersity index of developed formulation F2 found to have 326 nm and 0.482 respectively, determined by zeta sizer. Encapsulation efficiency of formulation F2 was found to have 68.34%. Formulation F1, F2 and F3 followed order release kinetics and formulation F4 and F5 followed Peppas-Korsmeyer.

Biography:

Zayyanu Shitu is an MSc student at Faculty of health science, Universiti Sultan Zaianal Abidin, Kuala Terengganu Malaysia, under the supervision of Professor Dr. Ab Fatah Bin Ab Rahman. He is currently conducting a research on the prevalence and associated factors of medication error in a Malaysian Hospital. So far he has published one paper, with three more in view.

Abstract:

Medication error (ME) is the harm caused to the patients during medication process in the hands of both healthcare practitioners and patients. It continues to pose a significant problem to health care systems across the world, not only causing harm and death in hospital patients but also consuming approximately $42 billion annually in healthcare expenditure. Little is known about associated factors of ME in the emergency department (ED) of hospitals in Malaysia. The objective of this study was to determine the factors associated with ME in an ED of hospital. A cross-sectional study was conducted on patients who visited the ED of Hospital Universiti Sains Malaysia over nine weeks (8 am – 5 pm). A total of 547 Patient’s demographic information, clinical characteristics, medication orders and procedures were observed and recorded using a designed data collection form, out of which 311 patients were selected randomly. Multiple logistic regression was employed to determine factors associated with ME among the observed patients. 95 (30.5%) of the patients had at least one ME. The factors found to be associated with ME were number of medications (poly-pharmacy) [adjusted (OR) 1.91 (95%CI: 1.51, 2.41)], Triage [adjusted (OR) 0.11 (95%CI: 0.04, 0.27)], Gender [adjusted (OR) 0.50 (95%CI: 0.26, 0.93)] and Time of patient visit [adjusted (OR) 0.34 (0.52, 0.75)]. Intervention measures such as the use of clinical pharmacist and informatics should take into account the associated factors.

Biography:

Dr. Jhanvi Vaghela is an MD student at Pharmacology Department, Government Medical College Bhavnagar & Maharaja Krishnakumarsinhji Bhavnagar University, Gujarat, India, under the supervision of Dean & Professor Dr. C.B.Tripathi. She is currently conducting a research on the therapeutic drug level monitoring of anti-epileptic drugs. So far she has published one case report in the journal current drug safety.

Abstract:

Glaucoma is a serious global health problem. It is the second leading cause for blindness globally and third leading cause of blindness in India. Glaucoma is a progressive optic neuropathy characterized by visual field changes and cupping of optic disc. Raised intraocular pressure (IOP) is one of important risk factor for glaucoma. Symptoms of glaucoma is photophobia, lacrimation, buphthalmos and blepharospasm. In folklore medicine the use of aloevera is described to reduce intra ocular pressure but not yet supported with experimental evidence. Aloe vera is a medicinal plant having proved anti oxidant, anti microbial, anti-proliferative, anti infflamatory and wound healing property.

Objective:

To evaluate anti glaucoma effect of Aloe barbadensis Miller gel in New Zealand White Rabbits.

Methods: 56 New Zealand White Rabbits (weight 1.5 – 2.5 kg) of either sex were randomly divided into 7 groups. Group 1: Normal Control,                 Group 2: Disease control, Group 3:   Active control (Timolol 0.5%), Group 4: 6 % Aloe barbadensis Miller gel, Group 5: 12 % Aloe barbadensis Miller gel, Group 6: 6 % Aloe barbadensis Miller gel + Timolol 0.5%, Group 7: 12 % Aloe barbadensis Miller gel + Timolol 0.5% . Intra ocular pressure is measured before increasing IOP and at 0 min, 15 min, 30 min, 1 hour, 2 hour, 4 hour, 8 hour, 12 hour, 24 hour, 36 hour and 48 hour. Pupil size, Light reflex and conjunctival colour in each group was also noted.

Results:

Statististically significant reduction in IOP  obtained in active control group, 6 % Aloe barbadensis Miller gel group, 12 % Aloe barbadensis Miller gel group, 6 % Aloe barbadensis Miller gel + Timolol 0.5% group, 12 % Aloe barbadensis Miller gel + Timolol 0.5% group when compared to Disease control group at 4 hour, 12 hour, 24 hour, 36 hour. Statististically significant reduction in IOP was found in 12% Aloe barbadensis Miller gel + Timolol 0.5% when compared to active controle group (Timolol 0.5% alone) at 12 hour, 24 hour and 36 hour.

Conclusion:

12 % Aloe barbadensis Miller gel reduces IOP and has shown promising results to be used as an add on remedy for additional anti glaucoma effect.

Biography:

Tijjani RG is a PhD student/ Graduate research assistant under the supervision of Prof. Dr. Norazlina Mohamed in the Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur. He is currently working on natural remedies for the management of osteoporosis in postmenopausal condition. So far, he has published more than 10 papers in reputed journals.

Abstract:

This study aims to investigate, in ovariectomized rats, the changes in bone biochemical markers induced by MPva leaf extract in an attempt to further evaluate its fracture-healing property. Thirty (30) healthy female Sprague-Dawley rats were sorted into five groups (n=6) namely: Sham-operated (SO); Ovariectomized control (OC); Estrogen treatment (ET); 20 mg leaf treatment (MP20); and 100 mg leaf treatment groups (MP100). All rats, except the SO group, were ovariectomized to induce a state of menopause. Eight weeks post-ovariectomy, the right tibiae of rats were fractured and fixed with titanium plates. For another 8 weeks, after osteotomy, the ET group was treated with 64.5μg/kg/d estrogen (Premarin^®) while the MP20 and MP100 groups were treated with 20mg and 100 mg/kg/d oral doses of MPva leaf extract, respectively. Before and after treatment, blood sample was collected from rats for assay of inflammatory markers while, after treatment, fractured tibiae were harvested from euthanized rats for assay of bone turnover and anti-oxidant markers using ELISA. At p < 0.05, results were considered significant. Serum level of osteocalcin was significantly elevated (p < 0.05) in MPv100 group while pyridinoline level was significantly elevated in all treatment groups as well as the OC. Post-treatment serum levels of IL-6 were significantly higher in MPv20 and MPv100 while TNF-alpha was significantly higher in MPv100 group compared to pre-treatment levels (p < 0.05). Levels of GPx and SOD in tibia were significantly elevated (p < 0.05) in both MPv20 and MPv100. Results obtained revealed that the bone-repair effects of MPva leaves could be exerted by its ability to enhance bone remodelling activities due to its anti-oxidant and inflammation modulatory properties.