Surendra Lalwani
Formulation and evaluation of extended release drug delivery system of metformin hydrochloride
Title: Surendra Lalwani
Biography
Biography: Surendra Lalwani
Abstract
Extended release pharmaceutical products became a very useful tool in medical practice, offering a wide range of actual and perceived advantages to the patient. Oral extended release drug delivery system becomes a promising approach for those drugs that are given orally, having the shorter half- life and high dosing frequency. Extended release provides promising way to decrease the side effect of the drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. Recent trends indicate that multi particulate drug delivery systems are especially suitable for achieving extended release oral formulations with low risk of drug dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. The release of drug from pellets depends on the variety of factors including the carrier used to form pellets and the amount of drug contained in them. Consequently, pellets provide tremendous opportunities for designing new controlled and extended release oral formulations, thus extending the frontier of future pharmaceutical development. In the present study extended release tablets of Metformin hydrochloride (an oral antihyperglycemic drug) were formulated by using polymers of different viscosity grade such as HPMC K4M, HPMC K15M, HPMC K100M by wet granulation method. The formulated granules blends were evaluated for compatibility, angle of repose, true density, bulk density, compressibility index. The formulated tablets were subjected to thickness, weight variation test, hardness test, friability test and drug content. In vitro dissolution studies carried out in 6.8 phosphate buffer using the apparatus Type 2 paddle type as described in the USP dissolution monograph. The best extended performance and the best in vitro drug release profile were achieved by formulation F5 which contains drug; HPMC K4M in a ratio of 1:6. The tablets were released the drug up to 12hr and had maximum extended lag time. There was no significant change in physical and chemical properties of the tablets of formulation F5 after 3 Months, parameters like % drug release and assay values at various conditions as per ICH guidelines.