Ramakrishna Shabaraya
Srinivas College of Pharmacy, India
Title: A study on antimalarial potency of artesunate liposomes
Biography
Biography: Ramakrishna Shabaraya
Abstract
Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. Artesunate having a short half life of 2-3hrs upon oral administration and is a lipophilic in nature is used for the treatment of malaria, was encapsulated in liposomes. The liposomes containing Artesunate were prepared using thin film hydration method. In this study, PEGylated and conventional liposomes containing artesunate were prepared using varying drug-lipid ratio and were characterized for their particle size, zeta potential, encapsulation efficiency, and in-vitro drug release studies. The drug encapsulation efficiency of PEGylated liposomes was found to be higher in comparison to conventional liposomes. The average particle size of both conventional and PEGylated liposomes was obtained in nanometers with PDI ranging from 0.095-0.356. The PEGylated liposomes were found to be more stable than the traditional liposomes through the zeta potential studies. In-vitro drug diffusion studies was carried for period of 16 hrs where PEGylated liposomal formulation showed around 80.99% sustained drug release which was more than the conventional liposomes. The PEGylated liposomal formulations followed Higuchi model where as conventional liposomal formulations followed zero order kinetics.