16^th Annual Medicinal & Pharmaceutical Sciences Congress October 16-17, 2017 Seoul, South Korea

Biography:

Nelly suryani is a lecture in pharmacy department of faculty of medicine and health science, stated islamic universit Syarif Hidayatullah Jakarta, Indonesia. Her interested field of study is pharmacy practice and pharmacy technology.

Abstract:

Objective: The objective of this research was to evaluate the influence of pH and light towards Potassium Losartan that suspends in water.

Methods: In this study, the percentage of losartan potassium suspension concentration was measured using High-Performance Liquid Chromatography based on the method of United Stated Pharmacopeia. Losartan Potassium Suspension was tested with variant condition which was suspended in pH 4 and pH 7 with protected and unprotected light condition, the testing is done by sampling at a time 0, 15, 30, 45, and 60 minutes

Results: The results showed that the suspension Losartan Potassium can be stored until the 45 minute with the concentration 98.63255% for pH 4 with unprotected light condition; 98.89277% for pH 7 with unprotected light condition; 98.55745% for pH 4 with protected light conditions; and 99.0656% for pH 7 with protected light condition. The result of this study showed after 45-minute losartan potassium suspension did not meet the requirement in the monograph which is 101.0 to 98.5%.

Conclusion: This research showed that the effect of pH and light on Losartan Potassium suspension did not give a significant difference.

Keywords: Suspension, Losartan Potassium, pH, light.

Biography:

Yardi is a lecture in pharmacy department of faculty of medicine and health science, stated islamic universit Syarif Hidayatullah Jakarta, Indonesia. His interested field of study is pharmacy practice and Pharmacology.

Abstract:

Background : Spironolactone is one of frequently drug used for heart desease as diuretic. For very old patient or patien in coma condition, this drug togather with others is administered as suspension in hospital.

Objective: The objective of this research was to understand at the comparison of two suspension methods, Crushing Suspension Method and Simple Suspension Method towards decreased contents of Spironolactone.

Methods: In this study, the percentage of Spironolactone concentrations of both suspension methods was measured using High Performance Liquid Chromatography based on methods of United State Pharmacopeia. The test was conducted by sampling at 0, 15, 30, 45, and 60 minutes.

Results: The results showed that there was a changing of Spironolactone contents with both of suspension method. In Crushing Suspension Method 93,9505% - 89,2399% and Simple Suspension Method 97,2743% - 95,1559%.

Conclusion: Simple Suspension Method is the ideal suspension method used because it can maintain Spironolactone drug contents as monographic requirements which is 95% - 105%.

Biography:

Maryam Hamzeloo-Moghadam research interests include cytotoxic evaluation and apoptotic induction of natural products along with exploring the traditional manuscripts for biological evaluation or preparation of modern dosage forms.

Abstract:

Statement of the Problem: Processed Capparis spinosa fruits, have been used in Iranian Traditional Medicine (ITM) for treatment of various diseases; the fruits are believed to have hot and dry temperament. The present study was designed in order to find the impact of processing on some phytochemical constituents and biological activities of Capparis spinosa. Methodology & Theoretical Orientation: The fruits were collected from Parsabad Moghan, Ardebil, Iran (2016) and processed with grape vinegar for 30 days. Total phenolics and alkaloids contents of the raw and processed fruits were determined. For quantitation of rutin and quercetin, R-HPLC with C18 column, methanol: formic acid 1% as the mobile phase (gradient), λ_max 257 nm was used. Cytotoxic activity of the fruits was determined by MTT method. Antioxidant properties were evaluated by DPPH and FRAP techniques. Fingerpriting of raw and processed fruits were prepared using TLC with silica gel as the stationary phase and n-butanol: acetic acid: H₂O 40:10:10 as the mobile phase. Findings: Total phenolics decreased in the processed fruits (7.5 times). Rutin concentration did not change during processing but quercetin amount decreased. Total alkaloids content was reduced as well. While, total phenolics decreased, antioxidant activities of the processed fruits increased using both DPPH and FRAP methods. No cytotoxic effect was observed for the raw fruits on normal human fibroblast cells (AGO1522) up to the concentration of 1000 µg/mL; however, decrease in the viability was observed for the processed fruits at this concentration. The fingerprints of the fruits were different which admitted the change in the fruit constituents due to processing. Conclusion & Significance: In general, it seems that processing with vinegar reduced the unpleasant taste of the plant due to alkaloids and increased the antioxidant effects; therefore it would be more suitable for use in some diseases such as diabetes and hepatitis.