Biography
Biography: Nelly Suryani
Abstract
Objective: The objective of this research was to evaluate the influence of pH and light towards Potassium Losartan that suspends in water.
Methods: In this study, the percentage of losartan potassium suspension concentration was measured using High-Performance Liquid Chromatography based on the method of United Stated Pharmacopeia. Losartan Potassium Suspension was tested with variant condition which was suspended in pH 4 and pH 7 with protected and unprotected light condition, the testing is done by sampling at a time 0, 15, 30, 45, and 60 minutes
Results: The results showed that the suspension Losartan Potassium can be stored until the 45 minute with the concentration 98.63255% for pH 4 with unprotected light condition; 98.89277% for pH 7 with unprotected light condition; 98.55745% for pH 4 with protected light conditions; and 99.0656% for pH 7 with protected light condition. The result of this study showed after 45-minute losartan potassium suspension did not meet the requirement in the monograph which is 101.0 to 98.5%.
Conclusion: This research showed that the effect of pH and light on Losartan Potassium suspension did not give a significant difference.
Keywords: Suspension, Losartan Potassium, pH, light.