Yardi Bin Saibi
Stated Islamic Universit Syarif Hidayatullah Jakarta, Indonesia
Title: Comparing methods crushing suspension method and simple suspension method to decrease contents of Spironolactone
Biography
Biography: Yardi Bin Saibi
Abstract
Background : Spironolactone is one of frequently drug used for heart desease as diuretic. For very old patient or patien in coma condition, this drug togather with others is administered as suspension in hospital.
Objective: The objective of this research was to understand at the comparison of two suspension methods, Crushing Suspension Method and Simple Suspension Method towards decreased contents of Spironolactone.
Methods: In this study, the percentage of Spironolactone concentrations of both suspension methods was measured using High Performance Liquid Chromatography based on methods of United State Pharmacopeia. The test was conducted by sampling at 0, 15, 30, 45, and 60 minutes.
Results: The results showed that there was a changing of Spironolactone contents with both of suspension method. In Crushing Suspension Method 93,9505% - 89,2399% and Simple Suspension Method 97,2743% - 95,1559%.
Conclusion: Simple Suspension Method is the ideal suspension method used because it can maintain Spironolactone drug contents as monographic requirements which is 95% - 105%.