Pharmacogenomics

Pharmacogenomics is the study of the role of the genome in drug response. Its name reflects its combining of pharmacology and genomics. Pharmacogenomics can be defined as the technology that analyzes how the genetic makeup of an individual affects his/her response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with pharmacokinetics and pharmacodynamics (drug absorption, distribution, metabolism, and elimination), as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.

  • Translational Pharmacogenomics
  • Applications of NGS to Pharmacogenomics
  • Nutrigenomics
  • Toxicogenomics
  • Biomarker Translation and Testing
  • Cancer Pharmacogenomics
  • Pharmacogenitics & Individualized Therapy
  • Pharmacogenomics in Clinical Therapeutics

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